THIOL ISOMERASES – A POSSIBLE TARGET FOR THROMBOSIS CONTROL
نویسندگان
چکیده
منابع مشابه
Thiol isomerases in thrombus formation.
Protein disulfide isomerase (PDI), ERp5, and ERp57, among perhaps other thiol isomerases, are important for the initiation of thrombus formation. Using the laser injury thrombosis model in mice to induce in vivo arterial thrombus formation, it was shown that thrombus formation is associated with PDI secretion by platelets, that inhibition of PDI blocked platelet thrombus formation and fibrin ge...
متن کاملIntracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.
OBJECTIVE Thiol isomerases facilitate protein folding in the endoplasmic reticulum, and several of these enzymes, including protein disulfide isomerase and ERp57, are mobilized to the surface of activated platelets, where they influence platelet aggregation, blood coagulation, and thrombus formation. In this study, we examined the synthesis and trafficking of thiol isomerases in megakaryocytes,...
متن کاملIntracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases
Crescente, M., Pluthero , F. G., Li, L., Lo, R. W., Walsh, T. G., Schenk, M. P., Holbrook, L. M., Loureiro, S., Ali, M. S., Vaiyapuri, S., Falet, H., Jones, I. M., Poole, A. W., Kahr, W. H. A. and Gibbins, J. M. (2016) Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases. Arteriosclerosis Thrombosis and Vascular Biology, 36 (6). pp. 1164-1173. ISSN 1079-5...
متن کاملThiol isomerases negatively regulate the cellular shedding activity of ADAM17.
ADAM17 (where ADAM is 'a disintegrin and metalloproteinase') can rapidly modulate cell-surface signalling events by the proteolytic release of soluble forms of proligands for cellular receptors. Many regulatory pathways affect the ADAM17 sheddase activity, but the mechanisms for the activation are still not clear. We have utilized a cell-based ADAM17 assay to show that thiol isomerases, specifi...
متن کاملPreparation and quality control of radiolabeled streptokinase for Thrombosis imaging
Background: In order to diagnose the site of thrombi, radiolabeled streptokinase can be prepared. The radiolabeled compound can be used in imaging of thrombi in many cardiovascular diseases. Materials and Methods: Streptokinase was successively labeled with [67Ga]-gallium chloride using cyclic DTPA-dianhydride. The conjugation with DTPA was optimized for concentration, time and temperature foll...
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ژورنال
عنوان ژورنال: Rational Pharmacotherapy in Cardiology
سال: 2017
ISSN: 2225-3653,1819-6446
DOI: 10.20996/1819-6446-2017-13-6-835-840